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NPR's Up First is the news you need to start your day. The three biggest stories of the day, with reporting and analysis from NPR News — in 10 minutes. Available weekdays by 6 a.m. ET, with hosts Rachel Martin, Noel King, Steve Inskeep and A Martinez. Also available on Saturdays by 8 a.m. ET, with Scott Simon. Subscribe and listen, then support your local NPR station at donate.npr.org.

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Omicron In US, Biden COVID Strategy, SCOTUS Abortion

The first case of the omicron variant has been identified in San Francisco, California, and experts say it could spread to the rest of the country in a matter of weeks. President Biden will unveil his COVID strategy today as coronavirus cases start to rise this winter. And, the Supreme Court looks poised to roll back abortion rights after hearing arguments in the Mississippi case.

Omicron In US, Biden COVID Strategy, SCOTUS Abortion

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Omicron Latest, SCOTUS Abortion, Michigan School Shooting

As the Omicron variant spreads rapidly around the world, uncertainty over vaccine efficacy is causing concerns. The Supreme Court will hear a case from Mississippi today to decide whether to reverse the court's landmark Roe v. Wade decision on abortion. And, several people were killed during a school shooting at Oxford High School in Michigan.

Omicron Latest, SCOTUS Abortion, Michigan School Shooting

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Omicron Latest, New York Prepares for Omicron, Gaza Rebuilding & Talks

The Biden Administration says it's preparing plans for the possibility that Omicron variant will emerge in US. As concerns over the new variant loom, New York's governor declared a state of emergency to help curb a winter surge of COVID cases. And, Israel is easing a blockade on the Gaza Strip, as diplomats work behind the scenes for a new agreement between old enemies.

Omicron Latest, New York Prepares for Omicron, Gaza Rebuilding & Talks

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Omicron Variant, Maxwell Trial, Virgil Abloh Obituary

Two cases of the newly identified omicron variant have been identified in Ontario, Canada, the U.S. is putting travel restrictions in place starting Monday. The trial of of Jeffery Epstein's alleged accomplice, Ghislaine Maxwell, is set to begin in a Manhattan federal court. And, legendary Black designer Virgil Abloh died on Sunday in Chicago after a two-year battle with a rare heart cancer.

Omicron Variant, Maxwell Trial, Virgil Abloh Obituary

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Investigations: CTE And Desperate Patients' "Last Hope"

CTE — chronic traumatic encephalopathy — is a degenerative brain disease found in many former professional football and hockey players, for whom blows to the head have long been part of the job.

Investigations: CTE And Desperate Patients' "Last Hope"

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New COVID Variant, Dow Has Worst Day of the Year, Stephen Sondheim Dies

A new coronavirus variant out of South Africa called Omicron has been designated by the World Health Organization as a "variant of concern." In response, Friday saw a massive selloff on Wall Street — a phenomenon that extended to Europe and Asia as well. And a titan of American musical theater, Stephen Sondheim, has died at age 91.

New COVID Variant, Dow Has Worst Day of the Year, Stephen Sondheim Dies

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New COVID Challenges, Iran Nuclear Talks, Holiday Shopping Kickoff

The World Health Organization evaluates a new COVID-19 variant, while the delta strain surges in other countries. Diplomats trying to revive a nuclear deal with Iran face new demands and a harder line from Tehran. Plus, holiday shopping could set records, despite inflation, shipping crises, and retail hiring struggles.

New COVID Challenges, Iran Nuclear Talks, Holiday Shopping Kickoff

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Arbery's Killers Found Guilty, Food Insecure Military Families, Sudan Protests

Three men found guilty of murdering Ahmaud Arbery in Georgia now face federal hate crime charges and possible life prison terms. An estimated 160,000 active military service members and their families have trouble putting food on the table. And mass protests in Sudan demand a return to full government control by civilians.

Arbery's Killers Found Guilty, Food Insecure Military Families, Sudan Protests

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White Nationalists Found Liable, Landmark Opioids Decision, Thanksgiving Travel Rush

A jury in Charlottesville, Virginia finds white nationalists and neo-Nazis liable for millions in damages from the 2017 Unite the Right rally. Jurors in Ohio determine that three of the country's biggest pharmacy chains helped fuel the opioid crisis. And what can Thanksgiving holiday travelers do to cope with what could be the biggest airport crowds in two years?

White Nationalists Found Liable, Landmark Opioids Decision, Thanksgiving Travel Rush

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Waukesha Parade Grief, Fed Chair Rerun?, Austria's New COVID Lockdown

Waukesha, Wisconsin mourns five who died when an SUV struck the city's Christmas parade. Lawmakers react to President Biden tapping Federal Reserve Chairman Jerome Powell for a second term. And Austria becomes the first European country to impose a new national lockdown to fight surging COVID infections.

Waukesha Parade Grief, Fed Chair Rerun?, Austria's New COVID Lockdown

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